A large population-based study indicates no strong association of KIR-/HLA-genotype and the risk of developing AML
Immunogenetic disease association studies may give rise to new hypotheses on the immunosurveillance of cancer. Polymorphic killer cell immuno-globulin-like receptor (KIR) genes and Acute Myeloid Leukemia (AML) have not been investigated so far in large population studies. For this purpose we typed the KIR and HLA genotype of German patients who were diagnosed with AML and compared their results to data of 51,890 German individuals who registered with DKMS. The current results suggest that there could be a weak association of KIR-genotype and HLA-C-KIR-ligand status combinations with the risk of developing AML.