Each patient, for whom a DKMS donor is being considered as a possible unrelated donor, must satisfy DKMS Registry’s requirements regarding diagnosis. Diagnoses that are a standard indication for HSCT do not need to fulfill further requirements. The classification into standard or rare indications is based on WHO´s guidelines:
Arber et al. (2016), `The updated WHO classification of hematological malignancies – The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia` In: BLOOD, 127:20, pp. 2391-2405.
If the indication for which the transplant center or registry is requesting a donor is not a standard indication for HSCT, DKMS Registry will consult its medical advisor and ask for an assessment of the case. In order to get a decision by the advisor, DKMS Registry may request further clinical information, e.g. an ethics committee vote, the study protocol or relevant case studies, from the transplant center or registry.
Each patient for whom an unrelated donor search is started at DKMS Registry must satisfy DKMS Registry’s requirements regarding age. If the age of the patient for whom the transplant center or registry is requesting a donor is above 80 years, DKMS Registry will consult a medical advisor and ask for an assessment of the case. In order to get a decision by the advisor, DKMS Registry may request further clinical information from the transplant center or registry.
In case of search initiation via EMDIS, the assessment takes place before the first donor request is completed, i.e. when it is clear that a DKMS donor might be of interest for the patient.
To search for unrelated donors at DKMS Registry, a donor search has to be initiated by sending relevant patient information. While a preliminary search request only provides match list results on potential stem cell donors, an active search must be started to perform donor requests (e.g. confirmatory typing).
Medical and personal data for search initiation
The following information must be provided in a preliminary search request from an international registry or transplant center:
DKMS Registry´s search algorithm Hap-E Search uses a probabilistic donor-recipient matching algorithm based on haplotype frequencies:
Urban, C., Schmidt, A. H., & Hofmann, J. A. (2020), `Hap-E Search 2.0: Improving the Performance of a Probabilistic Donor-Recipient Matching Algorithm Based on Haplotype Frequencies´, Frontiers in medicine, 7:32. https://doi.org/10.3389/fmed.2020.00032
Ranking of matching list
10/10 matching list:
9/10 matching list:
An approval by DKMS medical advisor is required when matching is <8/10.
8/10 matching results will be provided upon request via email (not via EMDIS).
DKMS Registry offers a special search support program to transplant centers in Chile, India, and Sri Lanka. DKMS Registry thereby assists transplant centers in these countries with their national and international unrelated donor and cord blood unit searches. All transplant centers using these services are evaluated according to WMDA criteria (See chapter 3). If you want more information about this program, please contact firstname.lastname@example.org.
All searches, preliminary and active, are free of charge. Searches for donors from DKMS UK, DKMS CL and DKMS BMST IN at DKMS Registry can be initiated in three different ways:
1. Via the European Marrow Donor Information System (EMDIS)
DKMS Registry (hub code = DR) is connected to several registries via EMDIS. Donor search requests as well as typing requests (TYP_REQ), sample requests (SMP_REQ), infectious disease marker request (IDM_REQ) and donor reservation requests (RSV_REQ) can be received via EMDIS.
2. Via E-Mail/Fax using WMDA forms
DKMS Registry also accepts requests by fax (Fax No. +49 7071 943 2299) or email (email@example.com) for all services. For requests by fax or email, we recommend the usage of WMDA forms (https://wmda.info/professionals/optimising-search-match-connect/wmda-forms), but we also accept other forms as long as they contain the information needed to perform the requested task.
DKMS Registry will send a search report, consisting of DKMS donor (UK, IN, CL) matching results and donor details of the most relevant donors, usually within one business day after receipt of the search request.
3. Via Donor Navigator® Software
International registries that are registered users of DKMS Registry´s web application Donor Navigator® can and are encouraged to initiate their donor searches and all subsequent requests through Donor Navigator® in case no EMDIS connection is available.
DKMS Registry expects the requesting registry to stop donor searches with DKMS Registry in case a donor is no longer needed for the patient. Reason for status change should be provided by EMDIS or other communication according to the EMDIS Semantics. DKMS Registry reserves the right to deactivate a donor search after a reasonable time of inactivity.