Estimating HLA haplotype frequencies

Int J Immunogenet, 2021;48:490–495.

Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report

Abstract

We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or

6 loci. Validation of our approach using a sample of over 3.4 million German individuals

was successful. Compared to an expectation-maximization algorithm, the errors were

larger. However, our approach allows the unequivocal detection of rare haplotypes.

Authors

Seitz, S., Lange, V., Norman, P. J., Sauter, J., Schmidt, A. H.

Publishing Date

09/27/2021