Models for KIR-genotype informed selection of HSC donors fail to predict outcome of patients with MDS or Secondary AML
Primary Objective
Harnessing NK-cell reactivity could thus reduce the risk of relapse after allogeneic hematopoietic cell transplantation (HCT). Several competing models have been proposed to classify donors, however, none of these entered clinical practice for unrelated donor selection. Our study showed that within our cohort of 1704 patients none of the models predicted the risk of relapse or death consistently.