Primary Objective

Several studies suggest that harnessing Natural Killer (NK) cell reactivity mediated through Killer-cell Immunoglobulin-like Receptors (KIR) could reduce the risk of relapse after allogeneic hematopoietic cell transplantation (HCT). Several competing models have been proposed to classify donors, however, none of these entered clinical practice for unrelated donor selection. Our study showed that within our cohort of 1,704 patients none of the models predicted the risk of relapse or death consistently.