Primary Objective

Improved donor selection based on immuno-genetic markers may improve outcome after allogeneic hematopoietic cell transplantation (alloHCT). One promising approach is the analysis of donor polymorphisms in immune response genes. Genetic variants encoded in the donor genomes may thus have an impact on the initiation, propagation and control of immune responses. This may be especially relevant for the risk for acute graft-versus-host disease. With the study we aim at elucidating the impact of genetic variation in 26 immune response genes. In total 37 genetic polymorphisms will be grouped according to different model assumptions and shall be investigated as risk factors for clinical endpoints after alloHCT.

For this study altogether 5,800 samples from donors shall be genotyped. All samples will be taken from the Collaborative Biobank.