This study aims at better understanding of the impact of variation in peripheral blood stem cell (PBSC) graft composition. Deeper insights into the relationship between the cellular composition and patient outcome after transplantation could lead to more precise criteria to define product quality or even personalized grafts customized to treat the individual patient’s condition. In addition, understanding correlations between genotype-phenotype or pre-mobilization donor peripheral blood cellular composition and graft composition could inform donor selection for mobilized stem cell products. This study will be by far the largest prospective study to investigate PBSC composition. It will create a unique opportunity to define the optimal cellular composition for the patients and to lower burden for the stem cell donor.
Additionally, one pillar of the collaborative study is to create a resource for future research on product characteristics in relation to patient outcome. To this end, cryopreservation of PBMCs from the donors collected at workup and an aliquot of PBSC is organized. Cryopreservation is conducted in such a way that the integrity and viability of the cells will be maintained. This will allow conducting a variety of different genetic, proteomic, metabolic and functional assays with those cells in future.