Severe blood disorders and cancer are the leading cause of death and disability from noncommunicable diseases in the global pediatric population and a major financial burden. Hemoglobinopathies are the most common life-threatening noncommunicable diseases in children [1]. Hematopoietic Stem Cell Transplantation (HSCT) can cure over 85% of low-risk children with Sickle Cell Disease (SCD) and Severe Thalassemia (ST) in lower-middle- and upper-middle-income countries [2], improves long-term health-related quality of life [3], and is cost-effective [4]. In many LMICs, BMT units are lacking, insufficient to meet the demand, or financially inaccessible to most patients [5]. Not infrequently, children requiring BMT and their families have to leave their home country, increasing hardship and perpetuating the hemorrhage of financial and human resources to more affluent countries.
Program Goals
With its Start-up Program for Pediatric BMT Centers in low- and middle-income countries (LMICs), DKMS intends to enable partners to locally offer safe and effective low-risk Hematopoietic Stem Cell Transplantation (HSCT) with a matched family donor for children suffering from Severe Thalassemia or Sickle Cell Disease. Following relatively inexpensive approaches in facilities that meet evidence-based quality standards pertinent to the expected HSCT case mix, this is viable in a sustainable manner.
The program, funded and administered by DKMS, is open for hospitals and tertiary care centers in haemoglobinopathy-prone areas, meeting certain conditions. It covers a time period of several years and is geared to the special needs of the respective center.
For further details regarding the scope of the program, requirements and the application process including relevant deadlines, please refer to the below guidelines.
As part of the DKMS Access To Transplantation (ATT) program, the Start-up Program for Pediatric BMT Centers intends to enable partners in LMICs (low- and middle-income countries) to locally offer safe and effective low-risk Hematopoietic Stem Cell Transplantation (HSCT) with a matched family donor for children suffering from Severe Thalassemia (ST) or Sickle Cell Disease (SCD) in a sustainable manner. This shall be facilitated by taking relatively inexpensive approaches in adequate facilities that meet evidence-based quality standards pertinent to the expected HSCT case mix.
The common goal shall be to reach 20 allogeneic transplantations during the first two years with three BMT rooms, using a cloud-based IT platform. As of the third year, 20 transplantations annually shall be reached. Partners must be willing to share outcome data and the costs per transplantation. Further, they should have the ambition to look into international accreditation according to FACT/JACIE standards.
The ATT program is funded and administered by DKMS.
The program is open to all hospitals and tertiary care centers in haemoglobinopathy-prone areas that provide standard of care for patients with Severe Thalassemia or Sickle Cell Disease or cooperate with centers that offer such care. Responsible body for the pediatric BMT center must be a non-profit corporate body or a legal entity of public law. Centers from all countries classified as low- and middle-income country by the World Bank are invited to apply.
The program covers a time period of several years and is geared to the special needs of the respective center.
The Program offers
In addition to the program, DKMS may consider
The program covers a large scope of support over several years, depending on the specific local needs. Beneficiaries are hence obliged to commit to defined requirements and regular reporting during the entire program.
BEFORE the start-up of the first transplantations, beneficiaries must be
AFTER the start-up of the first transplantations, beneficiaries must
The application process is divided in two steps: Firstly, an expression of interest which may, after a positive evaluation by DKMS, be followed by a full application. Provided documents will be reviewed and evaluated by the Medical Review and Advisory Group within 6 or 10 weeks after the application deadlines respectively. DKMS will inform the applicant in writing.
1. SKETCH (EXPRESSION OF INTEREST)
Centers interested in formally applying for the Start-up Program for Pediatric BMT Centers must as a first step hand in a sketch as an expression of interest. This must be signed by a medical responsible person, preferably the hospital management.
The sketch shall not exceed 5 pages and must include the following:
1. Organizational Form and Structure of the Center
a. Statement that the center is a non-profit corporate body or a legal entity of public law
b. Overview of medical departments, supporting staff etc.
2. Country- and Center-Specific Statistics
a. Relevant statistics on the population and health care services
b. Prevalence of severe hemoglobinopathies
c. Details about the centers patient base and provided standard of care for SCD or ST (as applicable). Information on availability of an outpatient clinics for these patients.
3. Patients/ Staff/ Stakeholders
a. How do patients currently access HSCT?
b. Which professionals are currently available at the center to potentially engage in HSCT (physicians & nurses)? How good are their English language skills?
4. Overall Start-up Motivation/ Strategy/ Approach
a. Reasons for the application, specific aims and objectives of the organization.
The sketch will be reviewed and evaluated by DKMS. If deemed eligible, the center will be invited to submit a full application based on a separate file provided by DKMS. Additional queries relating to the sketch may be raised and shall be addressed with the application.
2. FULL APPLICATION (BY INVITATION ONLY)
The application must be submitted in English language jointly with the cover sheet. It must cover all relevant details as required (separate checklist to be shared by DKMS).
The application checklist below should be used to ensure that the application is complete prior to submission. Incomplete applications will not be considered.
THE COMPLETE APPLICATION MUST INCLUDE THE FOLLOWING:
1. Cover Sheet (as provided by DKMS)
2. Checklist as provided by DKMS
3. Founding document/s that confirm the entity’s non-profit status (e.g. memorandum of incorporation, statutes, articles of association) or in case of a public center a confirmation letter of the governing authority. English translations of documents to be included, if applicable.
4. Outlook for the next three years including a business plan
5. Answers to DKMS queries relating to the sketch, if applicable.
Applications should be submitted to att@dkms.de. For each step there are two application deadlines annually:
SKETCHES must be received no later than by 31st October 2024 or 31st May 2025. An evaluation shall be performed no later than 6 weeks after the deadline and communicated to the applicant in writing.
FULL APPLICATIONS must be received no later than by 15th February 2025 or 15th August 2025. An evaluation shall be performed no later than 10 weeks after the deadline and communicated to the applicant in writing.
Accordingly, the program may start in May 2025 and November 2025 for selected centers.
Any application failing to meet the requirements of the program will be judged ineligible.
Applications will be treated as confidential documents. Only institutions that fulfil the applicable legal requirements from non-profit / charity law may be chosen as recipients under the program.
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